Oral Presentation Indian Ocean Rim Laboratory Haematology Congress 2014

alpha thalassemia with beta thalassemia co inheritance in different racial groups in Ahvaz (#30)

Mohammad Ali Jalali Far 1 2 , Najmaldin Saki 1 2 , Jamal Torabi Zadeh Maatoghi 3 , Hossein Hossieni 1 , Sadegh Negravi 4
  1. Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. Health Research Institute, Research Center of Thalassemia & Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. High Education and Research of Blood Transfusion Medicine, Tehran, Iran
  4. Department of English Language Teaching, College of Humanities, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

co inheritance of alpha thalassemia with beta thalassemia  can change the clinical manifestations and  and cause misdiagnosis.

In this cross sectional study we investigate all the people that referred to molecular diagnosis laboratory of Shafa hospital during 2010-2011. The ARMS- PCR,Gap –PCR and hemoglobin electrophoresis and RFLP were done for diagnosis of Alpha or beta thalassemia or hemoglobinopathies .The data was analyzed By SPSS15.

We found that 42 %( 8/19) was male, 36.8 % (7/19 ) pregnant women and 10.5%( 2/19) female and 10.5 (2/19 ) fetus. The race of our population was as the follow: 57.9 % was Arab, 20 % Lor and 15.8 % Bakhtiary. The prevalent mutation was -3.7/AA(63.2 %) and –A3.7/-A3.7 (26.3 %) and -A4.2/AA (5.2%).the prevalent mutations of beta chain was : -28(A>C), -88(C>A) , 5UTR+20(C>T), cd 6 (A>T)/cd 6,

Our findings showed the variable co inheritance in alpha thalassemia. The beta thalassemia and so different genotype can be influenced with the alpha thalassemia and leads to misdiagnosis in screening tests. The clinical manifestations in sickle cell alpha co inheritance diminished. Considering the co inheritance of alpha thalassemia with beta and prevalent hemoglobinopathies in counseling for marriage is highly recommended in our province.